Highlights
- • Beta-myrcene, beta-caryophyllene, & trans-nerolidol are Cannabis-derived terpenes with therapeutic potential.
- • Nanocarriers can improve the solubility and bioavailability of these volatile and hydrophobic terpenes.
- • Poly(lactide-co-glycolide) nanoparticles successfully encapsulated these three terpenes and enhanced activation of TPRV1 receptors.
- • Combinations of terpene-loaded NP formulations produced significantly higher calcium responses versus combinations of free terpenes.